Overview of Structural Genomics figure 12-1A: 12-B : Focus on BRCA1[breast cancer gene]

Sequence Hierarchy figure 12-2

The human alpha and beta hemoglobin gene families contain functional and pseudogenes. What is a pseudogene?

Tandem Repeats of Histone Genes in Sea Urchin and Fruit Fly.

Chromosome Ends or Telemeres

• Replication problem figure 12-5
• Tetrahymena adds TTGGGG figure 12-6
• t-loops
• Chromosome probes using FISH figure 12-7
• Heterochromatin in Drosophila is organized at centromeres- figure 12-8
• Mouse Chromosomes have centromeres at ends of chromosomes figure 12-9

VNTR - Variable Number of Tandem Repeats - figure 12-10

• Method of Obtaining DNA fingerprint using a VNTR figure 12-11

Retrotransposons propagate themselves by reverse transcriptase in corn these elements may constitute as much as 50% of the total DNA

Lines and Sines Long and Short Interspersed Elements are often equated with selfish DNA - figure 12-13 also figure 12-14

Mini- and Micro-satellite markers - insert

• figure 12-17
• figure 12-18
• figure 12-19

Additional Markers Rapids

Building chips

• Affimatrix http://www.affimatrix.com/

Chip Technology

Yeast Mapping -1

Yeast Mapping -2