The main roads that will lead you to Oxford are State Route 27, running north and south, and State Route 73, running east and west.
From the northeast
Take I-70 to State Route 127 south to State Route 73 west
From the northwest
Take I-70 to State Route 27 south
From the south
Take I-275 to State Route 27 north
From the southwest
Take I-74 to I-275 north/east to State Route 27 north
From the east
Take I-70 to State Route 127 south to 73 west
From the north
Take I-75 to State Route 73 west
