(1995) University of Kentucky
Areas of Expertise
Plant functional genomics, RNA biology,
molecular biology, biochemistry, and biotechnology.
Research in Dr. Li's lab focuses on the elucidation of plant mRNA polyadenylation mechanisms at the genetic, biochemical, and molecular levels. Funded by US National Science Foundation's Arabidopsis 2010 Project, and US National Institute of Health, we are using functional genomic tools to study the functions of a set of genes encoding plant polyadenylation factors. We are particularly interested in the regulatory role of mRNA polyadenylation in gene expression during plant development and stress responses.
Patrick E. Thomas, Xiaohui Wu, Man Liu, Bobby Gaffney, Guoli Ji, Q. Quinn Li and Arthur G. Hunt. 2012. Genome-wide control of poly(A) site choice by CPSF30 in Arabidopsis. Plant Cell, 24: 4376-4388. doi:10.1105/tpc.112.096107
Arthur G. Hunt, Denghui Xing, Q. Quinn Li. 2012. Plant polyadenylation factors: conservation and variety. BMC Genomics, 13:641. DOI: 10.1186/1471-2164-13-641
Hongwei Zhao, Jun Zheng, Q. Quinn Li. 2011. A novel plant in vitro assay system for pre-mRNA cleavage and polyadenylation. Plant Physiology, 157:1546-1554. Download paper
Yingjia Shen, R. C. Venu, Kan Nobuta, Xiaohui Wu, Varun Notibula, Caghan Demirci, Blake C Meyers, Guo-Liang Wang, Guoli Ji, Q. Quinn Li. 2011. Transcriptome Dynamics Through Alternative Polyadenylation in Developmental and Environmental Responses in Plants Revealed by Deep Sequencing. Genome Research, 21:1478-1486. Download paper
Xiaohui Wu, Man Liu, Bruce Downie, Chun Liang, Guoli Ji, Q. Quinn Li, Arthur Hunt. 2011. The genome-wide landscape of polyadenylation in Arabidopsis provides evidence for extensive alternative polyadenylation. Proc. Nat. Acad. Sci. USA, 108:12533-12538. doi/10.1073/pnas.1019732108 Download paper